A young surgeon with autism and Savant syndrome is recruited into the pediatric surgical unit of a prestigious hospital. The question will arise: can a person who doesn't have the ability to relate to people actually save their lives?
Cast: Freddie Highmore, Richard Schiff, Hill Harper, Nicholas Gonzalez, Antonia Thomas, Chuku Modu, Irene Keng, Beau Garrett, Jasika Nicole, Graham Verchere
As a barroom fight sends Dr. Shaun Murphy to seek treatment at St. Bonaventure's, Dr. Alex Park and Dr. Audrey Lim disagree over an elderly woman's post-operative symptoms.
Dr. Murphy is desperate to join the team on a dangerous procedure involving a tumor removal. However, having been removed from the surgery team by Dr. Han, Shaun must use his talents to help figure out the cause of an infant's injuries.
The new chief of surgery, Dr. Jackson Han, believes Dr. Shaun Murphy is a liability and works to keep him out of the operating room permanently.
Shaun's blunt honesty with a distraught mother of a critically ill newborn baby causes the new chief of surgery to question keeping him on as a resident.
Dr. Andrews tries to convince a grieving family to donate their teenage daughters face to another young girl whose face was horribly disfigured in an accident.
Dr. Shaun Murphy, Dr. Morgan Reznick and Dr. Audrey Lim treat a woman with autism and a delicate brain condition while navigating the complicated relationship she has with her roommate, who is also on the spectrum. Meanwhile, Lea and Shaun are still figuring out their friendship and roommate status.
In the aftermath of the quarantine, the staff tries to return to its normal routine; as Dr. Audrey Lim recovers from the virus, she and Dr. Neil Melendez navigate their new relationship; Dr. Shaun Murphy and Dr. Aaron Glassman try to relax.
Dr. Murphy feels overwhelmed by the chaos and noise in the emergency room; Dr. Reznick struggles to keep her patients alive; Dr. Lim fights for her life.
Dr. Murphy and Dr. Lim treat two patients who collapse at the airport and whose symptoms point to an airborne infection causing the hospital to go under quarantine.
Dr. Neil Melendez, Dr. Morgan Reznick and Dr. Claire Brown grapple with a patient's wish to perform an operation that would keep him from acting on his pedophilic urges; Dr. Shaun Murphy learns a lesson in empathy.
Dr. Shaun Murphy, Dr. Audrey Lim and Dr. Claire Brown's ER patient is forced to reveal a secret to her husband after their treatment caused a complication. Meanwhile, Dr. Neil Melendez, Dr. Morgan Reznick and Dr. Alex Park struggle with a patient whose parents don't believe in vaccination.
Dr. Shaun Murphy and Dr. Morgan Reznick must contend with two brothers who are bargaining over life and death. Meanwhile, Dr. Claire Brown's friend who is dying of cancer asks her for something she doesn't think she can give her; and Dr. Aaron Glassman is dealing with the effects of his treatment.
Morgan and Shaun are indecisive on how to treat a young violinist who has an infected finger; Lim, Claire and Park can't figure out if their young patient is actually ill or just looking for attention.
A patient suffering from anorexia can't gain the necessary weight needed to survive heart surgery, so Claire suggests they perform an experimental surgery which Melendez strongly opposes. Shaun worries Glassman's refusal to walk the hospital floor will keep him from being discharged and tries to persuade him to ambulate. Meanwhile, Shaun and Lea change the terms of their current relationship.
Shaun recalls his own past to help an intellectually disabled teenager face separation from his mother, while Claire is put between an injured teenage rock climber and her worried parents. Meanwhile, Glassman's post-op hallucinations force him to confront a personal tragedy.
Dr. Melendez, Dr. Brown and Dr. Park have given a young married couple two choices about their future: save the wife's life or their future ability to start a family. Meanwhile, when Dr. Lim has to take care of some personal business, she leaves oversight of the emergency room to Dr. Murphy and Dr. Reznick; and Dr. Glassman's post-op recovery leaves him struggling to get the rest he needs for recovery and also confronting his relationship with his daughter.
As Shaun pushes back against Dr. Melendez in order to treat a gravely ill hospital janitor, Dr. Lim risks a lawsuit to repair a teenage girl's ritual circumcision. Dr. Glassman exercises demanding oversight in choosing a doctor for his brain surgery.
Shaun's proposed treatment for a homeless patient puts him and Jared in Andrews' crosshairs. Meanwhile, Claire tries to overcome Melendez' reluctance to do a risky heart operation while Glassman must overcome his personal feelings about his oncologist, Dr. Marina Blaize, and face a difficult decision about his health.