In a wacky Rhode Island town, a dysfunctional family strive to cope with everyday life as they are thrown from one crazy scenario to another.
Cast: Seth MacFarlane, Alex Borstein, Seth Green, Mila Kunis, Mike Henry, Danny Smith, Patrick Warburton, John Viener, Alec Sulkin, Lori Alan, Ralph Garman, Adam West, Phil LaMarr, John G. Brennan, Wally Wingert
Stewie tries to erase himself from history when Peter and Chris constantly interrupt his TV time, only to end up as the baby of a British family.
Cleveland returns to Quahog, but is forbidden from spending time with Peter when their wives get into an argument over parenting.
Peter takes Meg to a college for an interview where they end up partying, while Brian is forced to live in the wild after a skunk sprays him.
Chris runs away with Jerome's daughter Pam, whom Jerome has forbidden Chris from dating, so Jerome must work with Peter to find their kids.
Lois calls Peter an idiot for bringing home the wrong baby after he takes Stewie to the park for some father-son bonding, so he goes to Chicago on a business trip and returns a smart, classy person.
Stewie gets herpes from Brian, while Peter and the guys discover that another group has taken their favorite booth at the Drunken Clam.
Peter is asked to be the face of an anti-smoking campaign after taking up smoking cigarettes, while Stewie helps Chris face school bullies.
When Chris is made the sole heir to Carter's fortune, he refuses to take the money, so Peter takes drastic measures to keep the wealth in the family.
Peter is sick of opposing football teams thanking God for beating the Patriots, so he and the guys go on a quest to find the Lord and ask Him to stop interfering in the outcomes of football games.
After Peter's mother passes away, he forms a special friendship with her longtime pal, Evelyn (guest voice Lauren Bacall), who attempts to seduce Peter. Meanwhile, Stewie is distraught when he understands the reality of death for the first time.
When Brian's neglected son Dylan shows up in town as a teen TV star, Brian jumps at the opportunity to be hired on the show's writing staff - instead of being a good father. Meanwhile, after Peter accidentally shoots Quagmire on a hunting trip, the two friends clash and Joe must choose a side.
Family Guy puts its own spin on three classic fairy tales, “Jack and the Beanstalk,” “Little Red Riding Hood,” & “Cinderella”
Lately Peter hasn't been able to perform very well in the bedroom. So he asks Quagmire and Joe to step in and help him get his mojo back.
When Carter Pewterschmidt cancels the annual Quahog Christmas carnival, because he hates the holiday, Peter must transform his father-in-law from a Scrooge into a hometown hero in order to salvage the event. Meanwhile, Stewie devises a master plan to get the one and only thing he wants for Christmas.
When Peter and Quagmire discover that their singing voices create beautiful harmony together, they form a singing/songwriting team, in the vein of Simon and Garfunkel. However, tensions run high when fame gets to Peter’s head.
When Stewie and Brian travel back to 17th century Jamestown, via Stewie’s time machine, they encounter too many close calls with altering the course of mankind. Stewie decides to destroy his time machine, but immediately regrets his decision when an unthinkable event happens and he is unable to go back in time.
The Griffins take a trip to Italy and are forced to deal with annoying immigration laws after Peter destroys the family’s passports.
Meg spills her lunch on the new kid, Michael, who is appropriately nicknamed “Mental Mike.” When he sets the date for her end on Friday, Meg tries to get out of it. Meanwhile, Peter continually harasses Brian in the nude until it escalates to the breaking point.
When Quagmire meets a woman named Sonja who is as sexually insatiable as he is, he is thrilled to finally be with someone who won't judge him. However, things take a turn for the worse when Sonja abducts Quagmire, intending to make him her sex slave. It is up to Peter, Joe and Quagmire's dad to explore the seedy underbelly of Quahog to find and rescue Quagmire. Meanwhile, a love triangle emerges between Stewie, Brian and Stewie's teddy bear, Rupert.
Peter discovers that he has a vestigial twin, whom he names Chip, growing out of his neck. It’s not long before Peter resents the fact that everyone seems to love Chip more than him, so he decides to amputate his twin. However, when Peter gets into trouble, he realizes he needs Chip more than ever.
Peter is convinced that a restaurant placemat is a treasure map. Word quickly spreads about the alleged cache, sparking a city-wide search and turning the citizens of Quahog against each other.