Former government agent Raymond "Red" Reddington (James Spader) has eluded capture for decades. But he suddenly surrenders to the FBI with an offer to help catch a terrorist under the condition that he speaks only to Elizabeth "Liz" Keen (Megan Boone), a young FBI profiler who's just barely out of Quantico.
Cast: James Spader, Megan Boone, Diego Klattenhoff, Ryan Eggold, Harry Lennix, Parminder Nagra, Hisham Tawfiq, Deborah S. Craig, Amir Arison
Liz and Red face off in a climactic race to find a Blacklister in possession of the duffle bag of bones, forcing the truth about the bones to finally come to light.
Samar lands in the crosshairs of an unconventional Blacklister, and Aram and the task force spring into action to find her before it's too late. Red journeys to Costa Rica to prevent the duffel bag of bones from being sold at an underground auction.
An unidentified young girl reappears and the team tries to find her connection to the secret Red is hiding. When her family steps in to protect their own secrets, the investigation turns into a race to save the girl's life.
Liz uses intel from an unexpected source to force a race with Red to uncover the secrets he holds, as Red initiates a plan to retrieve the duffel bag of bones.
In an attempt to apply pressure to Ian Garvey, Red and the Task Force head to Paris to track down a prominent heroin supplier for the Nash Syndicate. Distrustful of Red's agenda, Liz takes her own path in going after Garvey.
When an associate of the Nash Syndicate is murdered, Red sets Liz and the Task Force on the case in order to recover evidence crucial to bringing down Ian Garvey. Meanwhile, Aram considers a step forward in his relationship with Samar.
Liz investigates new details in a cold case from her early work as an FBI profiler. The Task Force takes action to bring down Tom's killers within the legal system, while Red takes an opposite approach.
As Liz continues tracking Tom's killers, Red tries to solve a tax issue in his money laundering. Meanwhile, Aram goes out to the field when the Task Force investigates a viral outbreak.
The Task Force tracks a Blacklister who develops airtight alibis for murderous clients. Meanwhile, Liz's reinstatement at the FBI hinges on evaluation.
Red points the Task Force toward a group that targets people with reprehensible but legal actions. As Red helps one of his employees, Liz discovers a clue about Tom's investigation.
As Liz works with Red to hunt for Tom's killers, she begins to question his motives. Meanwhile, the Task Force enlists the help of one arsonist to catch another.
Red goes on the hunt for a legendary treasure; Liz studies the methods of one of the Blacklist's most dangerous criminals.
When Red directs the Task Force to find a Blacklister who sells sensitive information; Ressler finds himself at risk of exposure; Liz plans her next move.
Liz abandons her old life for a fresh start in a new place, but she is forced to draw on her emotional and physical strength in a brutal fight when a threat finds her.
Tom goes missing and Liz desperately retraces his steps to find him; Red's hunt for the suitcase of bones leads to lives being changed forever.
Red and the Task Force place Dembe undercover to infiltrate an international human smuggling organization, but when communication is lost, they must intervene. Meanwhile, Tom's investigation into the suitcase lands him in grave danger.
While Cooper enlists Red on a case of personal importance, Ressler leads the Task Force to stop the resurgence of once-dormant murder-for-hire. Tom continues to investigate the suitcase despite a warning.
When Red provides exclusive intel on an international terrorist, it puts Liz and the Task Force on a collision course with a rival unit from the CIA. Meanwhile, Red and Hawkins lay the groundwork for their new business venture; and Tom goes undercover in search of information.
Liz and the Task Force hunt for an elusive criminal who is destroying the world's precious treasures. Meanwhile, a surprise encounter leads Red toward a new business opportunity, as Tom investigates the bones in the suitcase.
While the Task Force investigates a series of suspicious police shootings, Agent Ressler is distracted by increasing external pressures. With his back up against the wall, Red drafts Tom in executing an elaborate plan to help re-establish his criminal reputation.
Liz and the Task Force join Red in pursuit of a billionaire who moonlights as a high end art thief. Meanwhile, Dembe chases a lead and Tom seeks outside help in identifying the remains in the suitcase.
With his criminal empire in ruins, Red enlists Liz in a plan to earn cash and deliver a new Blacklister to the Task Force.