Former government agent Raymond "Red" Reddington (James Spader) has eluded capture for decades. But he suddenly surrenders to the FBI with an offer to help catch a terrorist under the condition that he speaks only to Elizabeth "Liz" Keen (Megan Boone), a young FBI profiler who's just barely out of Quantico.
Cast: James Spader, Megan Boone, Diego Klattenhoff, Ryan Eggold, Harry Lennix, Parminder Nagra, Hisham Tawfiq, Deborah S. Craig, Amir Arison
Liz discovers she's been framed by the cabal, prompting Red to tap into his connections to clear her name. Also: Cooper receives stunning news; and the task force is plagued by trust issues.
Following Red's intel, the FBI find themselves one-step behind the most dangerous Russian Assassin, Karakurt, an enemy on U.S. soil. To avoid catastrophe, Liz and Ressler meet with Russian Counter-Intelligence who offer insight not only on Karakurt, but also on the identity of Liz's mother. Cooper finds himself in a compromising position.
After decoding the information that is embedded in The Fulcrum, Red is determined to stop the imminent threat. Meanwhile, the task force discovers that deceased bodies of Chinese-American women are being smuggled out of the country under false identities. Liz continues to search for answers about her past after discovering a picture hidden in Red's secret flat.
As Red fights for his life, he pleads with Liz to track down a key figure from his past with knowledge of the Fulcrum.
The task force tracks a provocative female Blacklister, a frame-up artist who targets the wealthy elite. Tom pleads for Liz's help. Red pressures Liz for the Fulcrum, claiming it's now a matter of life and death.
The task force tracks a scientist who abducts disabled patients to conduct experiments on immortality. Now back in Washington, DC, Tom scrambles to save himself from new enemies.
As evidence mounts against Liz in the case of the murdered DC Harbormaster, a federal judge makes it clear to her that she will face severe criminal charges. Reddington and Ressler jump into high gear to exonerate Liz but the only solution is to find the recently vanished Tom Keen - wherever he may be operating in the world.
When Agent Keen is questioned in court as a suspect in the murder of the DC Harbormaster, her unusual relationship with Red and their task force falls under scrutiny. Meanwhile, Red enlists Cooper and Ressler to locate “The Major”, a dangerous former associate who is key in keeping Liz out of prison.
A former paramour involves Reddington in a deadly game with a wealthy and powerful family dynasty whose ill-begotten fortune was amassed from an underground auction of human and material contraband. Meanwhile, Tom takes on a new mission.
When Liz learns of a serial killer known as "The Deer Hunter" who tracks his victims like prey, Red helps the task force search for the killer. Meanwhile, the local DC police suspect the city Harbormaster was murdered as Liz struggles to keep her secret from unraveling.
When Red tips Liz off on the disappearance of Justin Kenyon, a polygamous cult leader with dangerous shipping containers buried on his property, the task force sets out to investigate. Meanwhile Red utilizes his sources to appease Fitch’s last words and travels to track down his hidden safe.
When an undercover CIA agent is kidnapped by a band of separatists in Uzbekistan, the task force sets a rescue mission in motion. Red informs Agents Keen and Ressler that they are up against Ruslan Denisov, a very dangerous past associate.
FBI boss Cooper tries to rescue his team in the wake of chaos at a detention facility. Elsewhere, thief Luther Braxton attempts to attain confidential information.
The task force tries to save Red when he's arrested and taken to a secret detention facility. At the facility, Red tangles with a thief with whom he shared a complicated history.
Red's plans for Berlin take a sudden turn after he finds out that he was manipulated by the latest Blacklister to avenge Red.
When an Iranian nuclear scientist is suspiciously assassinated, a revenge ploy begins against a valued American. Red informs agents Keen and Navabi that a dangerously conniving hitman “The Scimitar” has been sent to the job. Liz and Ressler find themselves in a tricky predicament as they investigate a surveillance lead. Agent Keen attempts to gather information on Berlin, while Red finds company with a woman working at a food truck.
When a mutilated corpse washes ashore, Agent Liz Keen consults Red over what he knows about the deadly underworld of wildlife poachers. Meanwhile Agent Donald Ressler develops a dangerous habit.
The team attempt to deal with an eco-terrorist cell who are after a deadly weapon. Red uses manipulation to pursue a special somebody.
Several nonviolent citizens all of a sudden become killers, prompting Red to think a dangerous socio-psychological experiment may be taking place. Naomi and her husband are given a complicated proposition.
When a man is found with his heart cut out, Agents Keen and Ressler team up with agent Samar Navabi to uncover the intricacies of Dr. Covington’s black-market operation. Meanwhile, Red and his associate try to capitalize on a new opportunity in Indonesia, leaving Reddington in a vulnerable position.
When the Monarch Douglas Bank is robbed, Red seizes the opportunity to try and take the money-laundering bank down. Liz questions Red’s intentions as she investigates the crime. Meanwhile, a new member joins Cooper’s taskforce after impressing everyone on the team.
Red continues to battle Berlin and faces a new threat from a man named Lord Baltimore. An important person comes back from the past into Red's world. Meanwhile, Liz tries to move forward with her life after her showdown with Tom.