Former government agent Raymond "Red" Reddington (James Spader) has eluded capture for decades. But he suddenly surrenders to the FBI with an offer to help catch a terrorist under the condition that he speaks only to Elizabeth "Liz" Keen (Megan Boone), a young FBI profiler who's just barely out of Quantico.
Cast: James Spader, Megan Boone, Diego Klattenhoff, Ryan Eggold, Harry Lennix, Parminder Nagra, Hisham Tawfiq, Deborah S. Craig, Amir Arison
With the crashing of the mysterious prisoner transport plane, the city is on lock down as the authorities are on the hunt for all the escapees. Meanwhile, with Red in custody, Liz uses her power to get him out since he is their best chance at finding all the suspects. Elsewhere, their main objective is to track down Berlin, a prisoner on the plane who is somehow involved.
Liz refuses to work with Red after discovering the truth about the death of her father. Seeking to make amends and force Liz to see him, Red brings the FBI a case they can't ignore. Meanwhile, Liz reveals what she knows about Tom's secret life to the FBI.
A politician in Prague finds himself being framed for murder, which sees the team attempting to take down the Kingmaker, a strategist who's behind the emergence of some powerful politicians.
The Pavlovich brothers specialize in abductions of high value targets and according to Red, they are planning their next hit. While the team tries to protect the next target, Red has a job of his own for the Pavlovich Brothers. Elsewhere, Liz patiently tries to uncover the truth about Tom.
Red and the team are on the hunt for "The Undertaker" - a life insurance claim adjuster who convinces ordinary people to become contract killers. Meanwhile, Liz works with Red to uncover Tom's secrets.
A Russian cyber terrorist known only as Ivan is suspected when a defense asset is stolen online. Liz and Red manage to uncover a huge cover up. New evidence comes to light in the case of Jolene's disappearance which in turn helps in the case of the mystery surrounding Tom.
One of Red's former associates, a crime lord, becomes the next target; Tom decides to confront Jolene.
When a prominent Prosecutor is found after being missing for 12 years Red believes that this is the work of Ruth Kipling also known as "The Judge." Only a myth, the Judge runs an underground criminal appeals process in which those who have wrongly imprisoned and punished others are judged and punished themselves. Meanwhile, Red investigates the woman who tempts Tom while in Orlando at a teacher's conference.
Liz helps Tom adjust to the impending adoption; Red reveals a woman from his past is a target; Red convinces Liz to pull of a heist at the Syrian Embassy.
As Liz (Megan Boone) heads up an investigation that exposes an adoption agency's shocking secret, Red's (James Spader) pursuit of the FBI mole identifies a surprisingly new suspect.
As Red (James Spader) enlists activist whistleblowers in his search for the mole, Liz (Megan Boone) pursues a deranged scientist who's helped dozens of criminals escape by engineering and killing their genetic doubles.
The entire FBI team is under investigation as internal affairs tries to find the mole. Elsewhere, Red is missing and conducts his own investigation into who betrayed him. Meanwhile, a serial killer from Liz’s past, "The Good Samaritan" strikes again. Liz is allowed to join the hunt for the killer as Cooper knows Red will likely reach out to help knowing how much this unsolved case means to Liz.
Liz infiltrates the blacksite and disarms the signal jammers to call in backup but runs into trouble along the way. The fate of Ressler hangs in the balance as Red tries to bargain with Anslo Garrick. Meanwhile, Tom becomes increasingly worried about Liz’ situation and the fate of Red is unknown.
Donald attempts to protect Red from a possible assassination attempt but is misled. The newest member on the blacklist, Anslo Garrick, infiltrates the FBI black site and tries to capture Red. Meanwhile Liz gets caught in an elevator and tries to figure out what is going on.
Red (James Spader) demands a deal from Cooper (Harry Lennix) before he'll agree to stop an anti-capitalist terrorist network's next deadly attack, while her dad's failing health reveals secrets in Liz's (Megan Boone) past.
Red (James Spader) leads Liz (Megan Boone) in the search for a deranged chemical weapons expert who unleashed a rare but fatal disease in the Washington, DC subway.
After Tom confronts Liz about the box - he claims he's innocent and insists that they turn it into the FBI so his name can be cleared. Elsewhere, Red informs Liz and the FBI that the next name on the Blacklist is beautiful and deadly corporate terrorist, Gina Zanetakos.
Red finds out that The Courier - a middle man that no one crosses - is delivering a package worth millions of dollars to an Iranian spy. Only the Courier is a ghost no one including Red, knows what he looks like. While racing to stop the mysterious criminal transaction, Liz, inadvertently finds herself thrust into a dangerous kidnapping plot. Meanwhile, Ressler must finally accept that Liz is a valuable asset to the team.
When a witness in the murder trial of a ruthless cartel boss disappears, Red (James Spader) leads Liz (Megan Boone) and Ressler (Diego Klattenhoff) on a search for the Blacklist's No. 161, a gruesome hit man known as the Stewmaker.
Red (James Spader) takes Liz (Megan Boone) on an undercover assignment to bring down a freelance Chinese spy who's targeting CIA agents.
Red predicts an impending catastrophe, rooted by the work of an assassin, called "The Freelancer". Together, Liz and Red go undercover to prevent from having his next target, Floriana Campo from being killed. Elsewhere, Ressler and newly re-hired CIA agent, Meera Malik, who's been added to Red's private security detail, keep an eye on them from a distance. Meanwhile, Liz considers what she should do next concerning Tom and the mysterious box she found hidden under the floorboards.
Ex-government agent and one of the FBI's Most Wanted fugitives, Raymond "Red" Reddington mysteriously turns himself in to the FBI and offers to give up everyone he has ever worked with including a long-thought-dead terrorist but under one condition - he'll only talk to newly-minted female FBI profiler, Elizabeth Keen with whom he seemingly has no connection. For Liz, it's going to be one hell of a first day on the job and what follows is a twisting series of events as the race to stop a terrorist begins.