An emotional thrill ride through the day-to-day chaos of the city's most explosive hospital and the courageous team of doctors who hold it together. They will tackle unique new cases inspired by topical events, forging fiery relationships in the pulse-pounding pandemonium of the emergency room.
Cast: Oliver Platt, S. Epatha Merkerson, Nick Gehlfuss, Yaya DaCosta, Colin Donnell, Brian Tee, Torrey DeVitto, Rachel DiPillo, Marlyne Barrett, Andre Bellos, Brennan Brown, Lorena Diaz, David Eigenberg, Julie Berman, Christina Brucato, Beth Chamberlin, Aislinn DeButch, Marika Engelhardt, Adam Farabee, Brian Geraghty, Marc Grapey, Sara Holden, Kara Killmer, Jodi Kingsley, Carl Lumbly, Amanda Marcheschi, James McCaffrey, Aaron Michael, Steve O'Connell, Maria Rivera, Sasha Rossof, Matthew Salter, Jeremy Shouldis, Chase Smith, Jesse Lee Soffer
Dr. Rhodes second guesses his decision to remove himself from the team of doctors who work to separate conjoined twins. Dr. Choi and April make a startling discovery about his sister, Emily, and Dr. Charles uncovers troubling information concerning Dr. Reese's father.
Dr. Manning rushes to save a young boy with a life-threatening case of the flu; April suspects Dr. Choi's sister stole opioid pain killers; Dr. Rhodes and Dr. Bekker disagree over the best treatment for a cardiac patient who is 21 weeks pregnant.
After a shooting occurs during a block party at a local park, Med is overrun with victims that stretch the hospital and staff to its limits. In the midst of the chaos, Dr. Choi devises a new mass casualty plan on the fly and Dr. Manning struggles to stay focused when she realizes her son and nanny might have been at the scene.
After a 10-year-old boy is admitted to the hospital, Dr. Manning and Dr. Halstead disagree on how to best handle the boy's parents. Dr. Rhodes rushes to fix a heart that will be given to Dr. Reese's estranged father.
Dr. Bekker takes the lead on a surgery, then takes the heat when something goes wrong.
A mother brings in her daughter claiming she's possessed; Rhodes and Bekker must save a pair of conjoined twins; Halstead tries to get Manning's attention; Maggie weighs her options.
Med goes on lock-down when a baby is abducted; Rhodes must figure out how to get into the operating room to help with an open-heart surgery; Manning and Halstead disagree on how a patient should be treated.
Halstead and Manning are at odds when a woman makes a decision about her vegetative adult son; Rhodes goes behind Bekker's to get his patient to the top of the transplant list; a woman in the waiting room won't wake up.
Dr. Manning and Dr. Choi help a pregnant teen deliver her baby at a homeless encampment.
Dr. Choi enlists April's help to figure out how a neighbor got stabbed; Noah misdiagnoses a patient.
Dr. Manning hits her head while helping the victim of a drive-by shooting; Dr. Rhodes learns surprising information about the woman he dated.
After discovering that a patient's family might have been abusive, Dr. Choi and April contemplate calling child services. Dr. Manning and Dr. Halstead struggle to see eye to eye in guiding a family who is dealing with their premature baby. Dr. Rhodes is persuaded into preforming a risky surgery on Dr. Bekker's mentor and world renowned surgeon, Dr. Marvin Jaffrey. Meanwhile, Dr. Reese joins Dr. Charles on a visit to the Cook County jail.
Dr. Choi struggles to help a woman cope with anorexia. After a two-week suspension, Dr. Reese is immediately put to the test upon her return by Dr. Charles. Dr. Rhodes takes a stand when one of his patients is forcibly transferred. Meanwhile, Dr. Halstead is on a mission to get Dr. Manning's son to like him.
Dr. Charles feels pressure when Dr. Choi and Dr. Manning criticize his medical decision regarding an ill newborn baby. Dr. Rhodes comes to terms with his relationship issues. Goodwin helps Bert understand Lyla's sickness.
Ethan attempts to diagnose a man with no symptoms while Sarah's paranoia goes to the extreme when she uses pepper spray on an aggressive patient. Will treats a young couple willing to sacrifice anything in order to have a baby. Meanwhile, Natalie must inform a woman that she was sterilized as a young girl without knowledge, and Goodwin and Maggie devise a way to persuade paramedics to bring in more patients.
When a young woman with HIV symptoms and no insurance refuses to take the test, Goodwin and Dr. Choi attempt to treat her without taking a toll on the hospital's resources. Natalie and Will try to diagnose a young girl with increasing paralysis. Noah deals with his first death as a resident and takes it upon himself to inform the family. Sarah continues to avoid work as her fear over the hospital's security increases.
Dr. Charles learns a troubling fact about the man who shot him. Dr. Rhodes and Dr. Bekker come to an agreement during a complicated surgery. Will and Natalie are trapped by legal ethics when an unfaithful husband refuses to tell his wife about his inconclusive Zika test. Meanwhile, April and Noah discover working together isn't always easy while Goodwin continues to argue with the board over hospital costs after an avoidable patient death.
When Goodwin receives financial complaints from the hospital board, she is forced to implement new guidelines that cause headaches for the doctors. Dr. Rhodes and Ava continue to compete in the operating room, while Dr. Charles and Dr. Reese are surprised when they treat a man who has a peculiar theory about his sickness. Dr. Manning and Dr. Choi can't figure out what is wrong with a young girl, leading them to look to a questionable source for answers.
Dr. Manning goes to extremely measures to help a fearful pregnant woman whose baby is severely underdeveloped. April is angered by Dr. Choi when he uses their personal relationship as leverage to convince a patient of a risky procedure. As Dr. Rhodes attempts to balance his personal and professional life, it appears the stress of his current situation may have caused him to make a huge mistake. Dr. Charles and Dr. Reese continue to disagree about their psych patients.
The doctors of Chicago Med attempt to bring the person who shot Dr. Charles to justice.