A group of people born on the same day, including Rebecca (Moore) and Jack (Ventimiglia), a married couple expecting triplets in Pittsburgh, and Kevin (Hartley), a handsome television actor growing bored of his fly bachelor lifestyle.
Cast: Jill Johnson, Mandy Moore, Milo Ventimiglia, Sterling K. Brown, Justin Hartley, Ron Cephas Jones, Chrissy Metz, Stephanie Ray, Chris Sullivan, Caitlin Thompson, Susan Kelechi Watson, Yimmy Yim
Jack heads to Cleveland to make things right with Rebecca on the night of her first gig; The Big Three make big decisions about their futures.
The family gather at Randall's for an unusual party; Kevin and Sophie's relationship deepens; Tensions are high between Jack and Rebecca.
Randall and William take a road trip to Memphis, where Randall learns about William's past.
Kevin stresses about his play; Randall struggles under pressure of work and William; Rebecca and Jack's Valentine's Day doesn't go as planned.
Toby throws a wrench in Kate's weight loss journey; Randall struggles to accept William's deteriorating health; Jack and Rebecca receive devastating news; Kevin examines his romantic past.
Jack and Rebecca throw their kids three separate 10th birthdays; Randall struggles to make time for William; Kevin makes a major decision in his love life; Kate's gastric bypass journey takes an unexpected turn.
As the triplets birth approaches, Rebecca forgets Jack's birthday; Dr. K tries to carry on without his wife; The firefighter who delivered Randall to the hospital, fights to save his marriage.
Kate struggles with Toby's heart attack; Jack and Rebecca learn they're having triplets; Olivia unexpectedly resurfaces.
The Pearsons discover Dr. K alone at the hospital on Christmas Eve after Kate's afflicted with appendicitis. In the present, Kevin celebrates Hanukkah with Sloane; Kate pursues her big surgery; and someone from William's past resurfaces.
Kate, Kevin and Randall visit their family's cabin after a chaotic Thanksgiving dinner; and a wedge is driven between Kate and Kevin after Olivia makes a harsh comment. In the past, a 9-year-old Randall reveals he's been searching for his birth parents.
Jack, Rebecca and the kids take an unexpected detour on their way to Thanksgiving dinner at Rebecca's parent's house. In the future, Kate makes two drastic decisions; Kevin invites Olivia to Randall's house for Thanksgiving; and Randall's heartbroken after learning a lifelong secret his mother kept from him.
Randall and Kevin's rocky relationship is explained; William unexpectedly reveals a secret to Beth; and Kate feels conflicted after Toby strays from his diet regimen. Elsewhere, Rebecca and Jack acknowledge the growing distance between them.
Kate interviews for a new job that seems perfect, but there's a catch; Randall has doubts about his career choice; and Kevin and Olivia's relationship takes a turn. In the past, Rebecca and Jack feel conflicted after Randall tests as a gifted child.
Rebecca and Jack argue about starting a family; and the family's history of Pittsburgh Steelers fandom is revealed. In the future, Kevin notices parallels between a character and his own life; and Beth and Randall encounter an unexpected turn of events.
Rebecca and Jake take the kids to a community pool, where they realize each child's unique struggles. In the future, Kevin auditions for a Broadway play; Toby runs into his ex-wife while on a date with Kate; and William's reported as a loiterer in Randall's predominantly white neighborhood, exposing deep-seated racial tensions.
Rebecca encounters Randall's biological father when she makes a surprise visit to her son's home; Kevin decides to move to NYC to pursue a job on Broadway; and Toby plans a special day for Kate. In the past, Rebecca and Jack take their new babies home from the hospital and struggle to cope with the loss of a child.
Toby helps Kate relax in the midst of her fervent quest to lose weight; and Beth questions the motives of Randall's biological father, as Randall adjusts to having his dad in his life. Meanwhile, Rebecca and Jack begin to feel distant from one another; and Kevin faces the consequences of quitting his job.
Several people whose lives are mysteriously intertwined begin to notice peculiar coincidences about each other in the series premiere of this dramedy.