Grey\'s Anatomy is a hospital drama that focuses on Meredith Grey (Ellen Pompeo), one of several third year residents at a Seattle Grace hospital. Along with her colleagues, Meredith struggles to maintain relationships while staying sharp at work. The professional roles and real lives of a diverse group of surgeons collide unexpectedly in this Golden Globe-winning ABC television drama.
Cast: Ellen Pompeo, Sandra Oh, Justin Chambers, Chandra Wilson, James Pickens Jr., Patrick Dempsey, Katherine Heigl, T.R. Knight, Sara Ramirez, Eric Dane, Chyler Leigh, Isaiah Washington, Kate Walsh, Kevin McKidd, Jessica Capshaw
In the second part of the two hour season finale, George delivers stunning news to Bailey, sending shockwaves throughout the hospital, and Izzie's friends anxiously await her recovery from surgery. Meanwhile Bailey is surprisingly displeased after being accepted into the pediatric fellowship program, and the victim of a near-fatal traffic accident brings the talents of Seattle Grace's doctors together. This is the second hour of a 2-hour season finale. Two episode entries have been created. The 10pm EST marker will mark to beginning of this episode.
Izzie's memory problems panic Alex, the team takes care of a John Doe who was hit by a bus, Bailey rethinks her pediatrics fellowship, and the hospital endures losses.
Izzie is torn over whether to have Derek's proposed brain surgery. A soldier on medical leave asks for a radical operation so he can return to active duty. The Chief tries to lure Bailey back to general surgery with a new toy, and Mark shifts into high gear with major life changes.
A car crash involving students going to their college graduation takes its toll on the residents in the ER, Derek's wedding gift is uniquely suited for Meredith - even if the oversight is not. Meanwhile, Denny's return has Derek and Bailey searching for the cause, and the results will change the outcome of the day.
Izzie's mother comes to town, a little girl shoots her father, triggering a conflict between Meredith and the chief, Thatcher reappears, and Callie gets her first taste of life without her trust fund.
Izzie bites off more than she can chew on her first day of chemotherapy, Mark and Derek are forced to work on the same patient, Meredith's plans for a simple wedding take a turn, and Karev finds himself split between worry over Izzie and excelling as a resident.
Derek returns to operate on Izzie, who's friends use their duties as residents to avoid her, especially George, who feels betrayed because Izzie never told him about what was going on. Alex assists Mark on a case where an elderly lady's family do nothing but hover around, waiting for her to die and Meredith turns down Derek's proposal because she feels it's all for the wrong reasons.
As Derek continues his hiding in the woods, all hands are on deck in an effort to get him back. Izzie insists that Cristina keep her secret about her cancer, while snickers abound about Lexi's relationship with Mark, who undertakes the task of performing a facial transplant.
Derek falls apart after the death of his most recent patient, but Meredith is trying hard not to let him give up; Alex refuses to give up on a patient who had an epileptic seizure, while Izzie refuses to let the interns give up; the Chief has all but given up on everyone in the hospital and begins ranting like a madman.
A mistake in the clinic mixes Izzie's test results with someone else's and sends her on a mission; a mistake by a general surgeon sends Cristina on a mission of her own; a mistake in the operating room by Derek sends him over the edge and ends up squaring off with Addison over a patient.
Owen runs into someone very special from his past. Izzie employs her fellow doctors in a medical game made to help teach the interns. Naomi, Sam and Addison rush Archer to Seattle Grace and meet with Derek and Mark to save his life.
Cristina carries on an intense flirtation with Owen, Derek gets advice from everyone on how to propose, Izzie gets some tests done, and Bailey's promotion may stand in the way of a new career possibility.
Derek's death row patient attempts suicide and Meredith looks the other way while everybody scrambles for an organ donor. Lexi keeps stumbling into walls after putting Mark in a compromising position. Denny intensifies his time with Izzie and Cristina doesn't know what to think of her Army doctor with problems.
Derek refuses to let a death row inmate die from injuries sustained in a prison riot, Miranda refuses to let a little boy die because he can't get the badly-needed transplant, Denny refuses to let his relationship with Izzie die, Lexi won't let her budding relationship with Mark die, and Derek's visiting mother puts everyone's mother first on priority lists.
Bailey doesn't see eye to eye with the new pediatric surgeon on a case she's been involved in for some time. Derek doesn't see eye to eye with a patient who's on death row. Alex doesn't see eye to eye with the other man in Izzie's life, because he's not real, and Meredith and Cristina don't see eye to eye on anything, which means they aren't talking and Cristina looks elsewhere to vent. Callie and Mark DO see eye to eye on their own personal problem, though, which makes for some interesting times for both.
The race for a Resident's first solo surgery comes down to Cristina, who was disqualified because of the actions of her interns, while at the same time is put under pressure to secure the services of a new head in the cardio department. Patients include a couple of sisters who were in a car accident, and a woman whose surgery may, or may not, enable her to talk again.
The interns ask for help from Cristina and Meredith when their back room "study group" has a set back while Izzie continues to wrestle things in her mind by herself. Patients include a father of a teenager who refuses to sleep because she doesn't feel safe and a hypochondriac who's prognosis is not as bad as she feared, but the proposed cure is worse.
Meredith's best friend from college shows up on her doorstep and Cristina feels threatened by it. Meredith thinks Sloan is putting the moves on her half-sister and asks Derek to intervene, while the interns practice sutures on each other and Izzie still feels Denny's presence. Hahn is suddenly gone from Seattle Grace and everyone immediately feel at odds over her replacement.
The residents compete for the opportunity to be the first one to solo, but Izzie's demons return in the form of a patient of Dr. Hahn's, who finds out the real reason her patient still is waiting for a heart. The interns steal cadavers for practice, then have to fight the residents off to keep them.
The new military doctor brings a new training method to the residents and interns for dealing with trauma, while Miranda is presented with the task of treating a ten year old girl with an illness that's considered inoperable by many, including Dr. Hahn. Callie questions her preferences, while Meredith stumbles across an old doll while going through some of her mother's things, Lexi avoids George for not asking for her as an intern, and Alex questions what he and Izzie have between them.
It's George's first day as a resident includes being on a team of surgeons who are performing six kidney transplants in one day, which helps to distract him in seeing that Lexie has feelings for him. Meanwhile, Callie has problems in taking her relationship to the next level with Erica and Meredith feels slighted when her names is left out of the medical journal report on her clinical trial with Derrick.
Calllie worries over her first real date with Erica. Cristina stumbles upon a neglected area of the hospital.
Determined to reverse Seattle Grace's slide into mediocrity, the chief lays down some new rules for interns and residents with which no one's happy. Derek asks Meredith for further changes in her living arrangements. Lexie challenges Cristina's diagnosis for a patient with a persistent headache, and the chief's preoccupation with reputation blinds him to problems with the physical plant.
Meredith and Derek find that "happily ever after" isn't as easy as they hoped, Cristina finds interest in a military doctor, and the Chief is surprised to hear that Seattle Grace is no longer ranked as a top-tier teaching hospital.