The Cortez siblings set out for a mysterious island, where they encounter a genetic scientist and a set of rival spy kids.
Director: Robert Rodriguez
Cast: Antonio Banderas, Carla Gugino, Alexa Vega, Daryl Sabara, Steve Buscemi, Mike Judge, Danny Trejo, Cheech Marin, Matt O\'Leary, Emily Osment, Ricardo Montalban, Holland Taylor, Alan Cumming, Taylor Momsen, Christopher McDonald