Izzie is torn over whether to have Derek's proposed brain surgery. A soldier on medical leave asks for a radical operation so he can return to active duty. The Chief tries to lure Bailey back to general surgery with a new toy, and Mark shifts into high gear with major life changes.
Cast: Ellen Pompeo, Sandra Oh, Katherine Heigl, Justin Chambers, T.R. Knight, Chandra Wilson, James Pickens Jr., Sara Ramirez, Eric Dane, Chyler Leigh, Kevin McKidd, Patrick Dempsey, Jeffrey Dean Morgan, Kimberly Elise, Jessica Capshaw