The interns, now residents, deal with their own crops of interns. Callie struggles with her new position, and Burke makes a decision.
Cast: Ellen Pompeo, Sandra Oh, Katherine Heigl, Justin Chambers, T.R. Knight, Chandra Wilson, James Pickens Jr., Sara Ramirez, Eric Dane, Chyler Leigh, Patrick Dempsey, Mark Pellegrino, Sandra Thigpen, Stephanie Childers, Steven M. Porter